|Normal Bone Structure|
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- Family history of Paget's disease, especially in a parent, sibling, or child
- Race: Anglo-Saxon, European
- Age: 40 or older
- In United States, residence in northern states
- Swelling or deformity of a limb
- Increased head size
- Bowing of a limb
- Curvature of the spine
- Chronic bone pain, especially legs, hips, or spine
- Frequent fractures
- Problems with walking or gait
- Headaches, facial pain, or hearing loss (when the skull bones are affected)
- Swollen or painful joints due to damaged joint cartilage
- Numbness, tingling, pain, or weakness from pressure on nerves
- Pain medicine—such as acetaminophen (Tylenol) or nonsteroidal anti-inflammatory drugs
- Bisphosphonates—usually by tablet or by injection
- Calcitonin—administered by injection or nasal spray
- Bone fracture
- Severe degenerative arthritis
- Bone deformity
- Calcium, usually about 1,000-1,500 mg per day
- Adequate exposure to sunshine to promote vitamin D production in the skin (but, limit time in the sun to prevent sun burning, wrinkling, and aging)
- Intake of adequate vitamin D, usually about 400 mg per day (older people may need more)
- Regular exercise to maintain skeletal health, joint mobility, and normal body weight
- Avoidance of excess mechanical stress on involved bones
- A splint for an area at high risk for fracture
NIH Osteoporosis and Related Bone Diseases National Resource Center http://www.niams.nih.gov/Health%5FInfo/Bone
The Paget Foundation http://www.paget.org
The Arthritis Society http://www.arthritis.ca
Osteoporosis Canada http://www.osteoporosis.ca
Albagha OM, Genetic Determinants of Paget's Disease (GDPD) Consortium. Genome-wide association identifies three new susceptibility loci for Paget's disease of bone. Nat Genet. 2011;43(7):685-689.
Michou L, Brown JP. Emerging strategies and therapies for treatment of Paget's disease of bone. Drug Des Devel Ther. 2011;5:225-239.
National Institutes of Health Osteoporosis and Related Bone Diseases, National Resource Center website. Available at: http://www.niams.nih.gov/Health%5FInfo/Bone. Accessed October 11, 2005.
Questions and answers about Paget's disease of bone. The Paget Foundation website. Available at: http://www.niams.nih.gov/Health%5FInfo/Bone. Published 2008. Accessed July 24, 2009.
Schneider D, Hofmann MT, et al. Diagnosis and treatment of paget's disease of bone. Am Fam Physician. 2002;15;65(10).
- Reviewer: Lawrence Frisch, MD, MPH
- Update Date: 09/27/2011 -